Ключові слова
хронічний панкреатит, зовнішньосекреторна недостатність підшлункової залози, якість життя, тривалість життя, замісна ферментна терапія
Як цитувати
Gubergrits, N. B., Byelyayeva, N. V., KlochkovА. Y., LukashevichG. М., Fomenko, P. G., & Rachmetova, V. S. (2018). Замісна ферментна терапія та якість, тривалість життя хворих на хронічний панкреатит із зовнішньосекреторною недостатністю підшлункової залози. Вісник клубу панкреатологів, 40(3), 10-16. https://doi.org/10.33149/vkp.2018.03.02
Переглядів анотації: 1151 Завантажень PDF: 457 Завантажень PDF: 186
Анотація
У статті проведено огляд доказових досліджень, присвячених оцінці ефективності і безпеки замісної ферментної терапії у хворих на хронічний панкреатит із зовнішньосекреторною недостатністю підшлункової залози. Особливу увагу приділено впливу замісної терапії на якість і тривалість життя хворих. Доведено, що правильне призначення ферментних препаратів (мінімікросферичного препарату з ентеросолюбільною оболонкою, достатні дози) сприяє підвищенню якості та збільшенню тривалості життя пацієнтів.
Посилання
1. Bhutani M. S. Pancreas and biliary tract diseases / M. S. Bhutani, P. Vilmann, A. Saftoiu. — Oxford (UK) : Health Press, 2017. — 149 p.
2. Cardiovascular risk (CVR) associated with pancreatic exocrine insufficiency (PEI) in patients with chronic pancreatitis (CP) / N. Vallejo-Senra, D. De la Inglesia-Garcia, A. Lopez-Lopez [et al.] / 48th European Pancreatic Club (EPC) meeting // Pancreatology. — 2016. — Vol. 16, No 3S1. — P. S80.
3. Clinical pancreatology for practicing gastroenterologists and surgeons / Ed. : J. E. Dominguez-Munoz. — Oxford [et al.] : A Blackwell Publishing Company, 2005. — 535 р.
4. 13C-mixed triglyceride breath test to assess oral enzyme substitution therapy in patients with chronic pancreatitis / J. E. Dominguez-Munoz, J. Iglesias-Garcia, M. Vilarino-Insua [et al.] // Clin. Gastroenterol. Hepatol. — 2007. — Vol. 5. — P. 484–488.
5. The daily practice of pancreatic enzyme replacement therapy after pancreatic surgery : a northern European survey: enzyme replacement after surgery / E. C. Sikkens, D. L. Cahen, C. van Elick [et al.] // J. Gastrointest. Surg. ― 2012. ― Vol. 16, No 8. ― P. 1487–1492.
6. Dominguez-Munoz J. E. Pancreatic exocrine insufficiency: diagnosis and treatment / J. E. Dominguez-Munoz // J. Gastroenterol. Hepatol. — 2011. — Vol. 26, Suppl. 2. — P. 12–16.
7. The effects of oral pancreatic enzymes (Creon 10 capsule) on steatorrhea: a multicenter, placebo-controlled, parallel group trial in subjects with chronic pancreatitis / M. Safdi, P. K. Bekal, S. Martin [et al.] // Pancreas. ― 2006. ― Vol. 33, No 2. ― P. 156–162.
8. Increased risk of mortality associated with pancreatic exocrine insufficiency in patients with chronic pancreatitis / D. de la Iglesia-Garcia, N. Vallejo-Senra, J. Iglesias-Garcia [et al.] // J. Clin. Gastroenterol. ― 2017. ― [Epub ahead of print].
9. Insulin dependence and pancreatic enzyme replacement therapy are independent prognostic factors for long-term survival after operation for chronic pancreatitis / M. Winny, V. Paroglou, H. Bektas [et al.] // Surgery. ― 2014. ― Vol. 155, No 2. ― P. 271–279.
10. Lindkvist B. Clinical, anthropometric and laboratory nutritional markers of pancreatic exocrine insufficiency: prevalence and diagnostic use / B. Lindkvist, M. E. Phillips, J. E. Dominguez-Munoz // Pancreatology. — 2015. — Vol. 15. — P. 589–397.
11. Lohr J.-M. Exocrine pancreatic insufficiency / J.-M. Lohr. — Bremen : UNI-MED, 2010. — 91 p.
12. A 6-month, open-label clinical trial of pancrelipase delayed-release capsules (Creon) in patients with exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery / N. Gubergrits, E. Malecka-Panas, G. A. Lehman [et al.] // Aliment. Pharmacol. Ther. ― 2011. ― Vol. 33, No 10. ― P. 1152–1161.
13. Mortality, cancer, and comorbidities associated with chronic pancreatitis : a Danish nationwide matched-cohort study / U. C. Bang, T. Benfield, L. Hyldstrup [et al.] // Gastroenterology. — 2014. — Vol. 146, No 4. — P. 989–994.
14. Netter F. H. The Netter collection of medical illustrations / F. H. Netter. — New York : Colorpress, 2001. — Vol. 3. Digestive System, p. 3. — 200 p.
15. Pancreatic enzyme replacement therapy in patients with exocrine pancreatic insufficiency due to chronic pancreatitis : a 1-year disease management study on symptom control and quality of life / J. G. D’Haese, G. O. Ceyhan, I. E. Demir [et al.] // Pancreas. ― 2014. ― Vol. 43, No 6. ― P. 834–841.
16. Pancreatic enzyme replacement therapy in post-pancreatectomy patients / M. Braga, M. Cristallo, R. De Franchis [et al.] // Int. J. Pancreatol. ― 1989. ― Vol. 5, Suppl. ― P. 37–44.
17. Pancreatitis: medical and surgical management / Eds. : D. B. Adams [et al.]. — Chichester : Wiley Blackwell, 2017. — 326 p.
18. Pancrelipase delayed-release capsules (CREON) for exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery : a double-blind randomized trial / D. C. Whitcomb, G. A. Lehman, G. Vasileva [et al.] // Am. J. Gastroenterol. ― 2010. ― Vol. 105, No 10. ― P. 2276–2286.
19. Pancreatology : a clinical textbook / Eds. : T. B. Gardner, K. D. Smith. — Cham (Switzerland) : Springer International Publishing AG, 2017. — 193 p.
20. Quality of life assessment after pancreatic enzyme replacement therapy in chronic pancreatitis / L. Czako, T. Takacs, P. Hegyi [et al.] // Can. J. Gastroenterol. ― 2003. ― Vol. 17, No 10. ― P. 597–603.
21. Randomised clinical trial: the efficacy and safety of pancreatin enteric-coated minimicrospheres (Creon 40000 MMS) in patients with pancreatic exocrine insufficiency due to chronic pancreatitis — a double-blind, placebo-controlled study / V. Thorat, N. Reddy, S. Bhatia [et al.] // Aliment. Pharmacol. Ther. ― 2012. ― Vol. 36, No 5. ― P. 426–436.
22. Some patients with irritable bowel syndrome may have exocrine pancreatic insufficiency / J. S. Leeds, A. D. Hopper, R. Sidhu [et al.] // Clin. Gastroenterol. Hepatol. ― 2010. ― Vol. 8, No 5. ― P. 433–438.
23. Testoni P. A. Acute and chronic pancreatitis: new concepts and evidence-based approaches / P. A. Testoni, A. Mariani, P. G. Arcidiacono. — Turin : Edizioni Minerva Medica, 2013. — 193 p.
24. Toskes P. P. Efficacy of a novel pancreatic enzyme product, EUR-1008 (Zenpep), in patients with exocrine pancreatic insufficiency due to chronic pancreatitis / P. P. Toskes, A. Secci, R. Thieroff-Ekerdt // Pancreas. ― 2011. ― Vol. 40, No 3. ― P. 376–382.
25. A 51-week, open-label clinical trial in India to assess the efficacy and safety of pancreatin 40000 enteric-coated minimicrospheres in patients with pancreatic exocrine insufficiency due to chronic pancreatitis / H. Ramesh, N. Reddy, S. Bhatia [et al.] // Pancreatology. ― 2013. ― Vol. 13, No 2. ― P. 133–139.
26. United European Gastroenterology evidence based guidelines for the diagnosis and therapy of chronic pancreatitis (HaPanEU) / J. M. Löhr, E. Domínguez-Muñoz, J. Rosendahl [et al.] // United European Gastroenterology Journal. — 2017. — Vol. 5, No 2. — P. 153–199.
2. Cardiovascular risk (CVR) associated with pancreatic exocrine insufficiency (PEI) in patients with chronic pancreatitis (CP) / N. Vallejo-Senra, D. De la Inglesia-Garcia, A. Lopez-Lopez [et al.] / 48th European Pancreatic Club (EPC) meeting // Pancreatology. — 2016. — Vol. 16, No 3S1. — P. S80.
3. Clinical pancreatology for practicing gastroenterologists and surgeons / Ed. : J. E. Dominguez-Munoz. — Oxford [et al.] : A Blackwell Publishing Company, 2005. — 535 р.
4. 13C-mixed triglyceride breath test to assess oral enzyme substitution therapy in patients with chronic pancreatitis / J. E. Dominguez-Munoz, J. Iglesias-Garcia, M. Vilarino-Insua [et al.] // Clin. Gastroenterol. Hepatol. — 2007. — Vol. 5. — P. 484–488.
5. The daily practice of pancreatic enzyme replacement therapy after pancreatic surgery : a northern European survey: enzyme replacement after surgery / E. C. Sikkens, D. L. Cahen, C. van Elick [et al.] // J. Gastrointest. Surg. ― 2012. ― Vol. 16, No 8. ― P. 1487–1492.
6. Dominguez-Munoz J. E. Pancreatic exocrine insufficiency: diagnosis and treatment / J. E. Dominguez-Munoz // J. Gastroenterol. Hepatol. — 2011. — Vol. 26, Suppl. 2. — P. 12–16.
7. The effects of oral pancreatic enzymes (Creon 10 capsule) on steatorrhea: a multicenter, placebo-controlled, parallel group trial in subjects with chronic pancreatitis / M. Safdi, P. K. Bekal, S. Martin [et al.] // Pancreas. ― 2006. ― Vol. 33, No 2. ― P. 156–162.
8. Increased risk of mortality associated with pancreatic exocrine insufficiency in patients with chronic pancreatitis / D. de la Iglesia-Garcia, N. Vallejo-Senra, J. Iglesias-Garcia [et al.] // J. Clin. Gastroenterol. ― 2017. ― [Epub ahead of print].
9. Insulin dependence and pancreatic enzyme replacement therapy are independent prognostic factors for long-term survival after operation for chronic pancreatitis / M. Winny, V. Paroglou, H. Bektas [et al.] // Surgery. ― 2014. ― Vol. 155, No 2. ― P. 271–279.
10. Lindkvist B. Clinical, anthropometric and laboratory nutritional markers of pancreatic exocrine insufficiency: prevalence and diagnostic use / B. Lindkvist, M. E. Phillips, J. E. Dominguez-Munoz // Pancreatology. — 2015. — Vol. 15. — P. 589–397.
11. Lohr J.-M. Exocrine pancreatic insufficiency / J.-M. Lohr. — Bremen : UNI-MED, 2010. — 91 p.
12. A 6-month, open-label clinical trial of pancrelipase delayed-release capsules (Creon) in patients with exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery / N. Gubergrits, E. Malecka-Panas, G. A. Lehman [et al.] // Aliment. Pharmacol. Ther. ― 2011. ― Vol. 33, No 10. ― P. 1152–1161.
13. Mortality, cancer, and comorbidities associated with chronic pancreatitis : a Danish nationwide matched-cohort study / U. C. Bang, T. Benfield, L. Hyldstrup [et al.] // Gastroenterology. — 2014. — Vol. 146, No 4. — P. 989–994.
14. Netter F. H. The Netter collection of medical illustrations / F. H. Netter. — New York : Colorpress, 2001. — Vol. 3. Digestive System, p. 3. — 200 p.
15. Pancreatic enzyme replacement therapy in patients with exocrine pancreatic insufficiency due to chronic pancreatitis : a 1-year disease management study on symptom control and quality of life / J. G. D’Haese, G. O. Ceyhan, I. E. Demir [et al.] // Pancreas. ― 2014. ― Vol. 43, No 6. ― P. 834–841.
16. Pancreatic enzyme replacement therapy in post-pancreatectomy patients / M. Braga, M. Cristallo, R. De Franchis [et al.] // Int. J. Pancreatol. ― 1989. ― Vol. 5, Suppl. ― P. 37–44.
17. Pancreatitis: medical and surgical management / Eds. : D. B. Adams [et al.]. — Chichester : Wiley Blackwell, 2017. — 326 p.
18. Pancrelipase delayed-release capsules (CREON) for exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery : a double-blind randomized trial / D. C. Whitcomb, G. A. Lehman, G. Vasileva [et al.] // Am. J. Gastroenterol. ― 2010. ― Vol. 105, No 10. ― P. 2276–2286.
19. Pancreatology : a clinical textbook / Eds. : T. B. Gardner, K. D. Smith. — Cham (Switzerland) : Springer International Publishing AG, 2017. — 193 p.
20. Quality of life assessment after pancreatic enzyme replacement therapy in chronic pancreatitis / L. Czako, T. Takacs, P. Hegyi [et al.] // Can. J. Gastroenterol. ― 2003. ― Vol. 17, No 10. ― P. 597–603.
21. Randomised clinical trial: the efficacy and safety of pancreatin enteric-coated minimicrospheres (Creon 40000 MMS) in patients with pancreatic exocrine insufficiency due to chronic pancreatitis — a double-blind, placebo-controlled study / V. Thorat, N. Reddy, S. Bhatia [et al.] // Aliment. Pharmacol. Ther. ― 2012. ― Vol. 36, No 5. ― P. 426–436.
22. Some patients with irritable bowel syndrome may have exocrine pancreatic insufficiency / J. S. Leeds, A. D. Hopper, R. Sidhu [et al.] // Clin. Gastroenterol. Hepatol. ― 2010. ― Vol. 8, No 5. ― P. 433–438.
23. Testoni P. A. Acute and chronic pancreatitis: new concepts and evidence-based approaches / P. A. Testoni, A. Mariani, P. G. Arcidiacono. — Turin : Edizioni Minerva Medica, 2013. — 193 p.
24. Toskes P. P. Efficacy of a novel pancreatic enzyme product, EUR-1008 (Zenpep), in patients with exocrine pancreatic insufficiency due to chronic pancreatitis / P. P. Toskes, A. Secci, R. Thieroff-Ekerdt // Pancreas. ― 2011. ― Vol. 40, No 3. ― P. 376–382.
25. A 51-week, open-label clinical trial in India to assess the efficacy and safety of pancreatin 40000 enteric-coated minimicrospheres in patients with pancreatic exocrine insufficiency due to chronic pancreatitis / H. Ramesh, N. Reddy, S. Bhatia [et al.] // Pancreatology. ― 2013. ― Vol. 13, No 2. ― P. 133–139.
26. United European Gastroenterology evidence based guidelines for the diagnosis and therapy of chronic pancreatitis (HaPanEU) / J. M. Löhr, E. Domínguez-Muñoz, J. Rosendahl [et al.] // United European Gastroenterology Journal. — 2017. — Vol. 5, No 2. — P. 153–199.