Substantiation of using the ursodeoxycholic acid in the treatment of non-alcoholic steatohepatitis
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Keywords

non-alcoholic steatohepatitis, treatment, ursodeoxycholic acid, physiological effects, evidence base

How to Cite

Gubergrits, N. B., Byelyayeva, N. V., Lukashevich, G. M., Fomenko, P. G., & Yuryeva, A. V. (2019). Substantiation of using the ursodeoxycholic acid in the treatment of non-alcoholic steatohepatitis. Herald of Pancreatic Club, 42(1), 78-83. https://doi.org/10.33149/vkp.2019.01.11

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Abstract

The article provides brief epidemiological data on non-alcoholic fatty liver disease and non-alcoholic steatohepatitis, emphasizing the danger of steatohepatitis, progression of which may cause the development of hepatocellular carcinoma. The properties of ursodeoxycholic acid, which are the basis for its use in a treatment of non-alcoholic steatohepatitis, are analyzed in detail, such as cytoprotective, antioxidant, antifibrotic ones, effects on apoptosis, etc. The authors presented the results of the main evidence-based studies demonstrating the effectiveness of ursodeoxycholic acid and its combinations with other drugs in the treatment of non-alcoholic steatohepatitis.

https://doi.org/10.33149/vkp.2019.01.11
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DOCX