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Abstract
The immune and nervous systems are characterized by such a property as memory. One of the functions of the immune system is to neutralize foreign information and maintain antigenic homeostasis of the body. Immunological memory is needed to reduce the time of response to an antigen in case of a repeated encounter with it. At the same time, the number of neurons practically does not change from birth to death, they do not proliferate. The limitation of proliferation is due to methylation. It is known that DNA in a chromosome consists of two chromatids. If the methylation pattern is symmetrical, then this cell is allowed to undergo mitotic division. If asymmetry is present, the cell continues to be in the resting phase.
A complete surprise was the identification of the activity of the proto-oncogenes c-Fos and c-Jun in the hippocampus of rats during neuronal activation. This occurred during the induction and training of spatial memory in animals. Having formed heterodimers, these proto-oncogenes triggered the transcription of subordinate genes. After some time, the transcriptional activity disappeared, but arose in the neurons of the cognitome and ultimately remained in neurons of the frontal cortex. The connection between the brain and tissues of the macroorganism and the microbiome is carried out through the transfer of small intercellular vesicles that overcome the blood-brain barrier in both directions and can correct the work of both the brain and the target tissue of the macroorganism.
Nowadays, a person continues to evolve or degrade depending on his inherent ethics and habits. The substrate of human evolution is the brain, which cannot be separated from other parts of the body (soma, according to R. Virkhov). Antigenic homeostasis of the human body is maintained by the immune system. For higher nervous activity, proto-oncogenes are required, which are involved in such a brain function as memory. It can be recalled that cancer patients are characterized by a clear mind to memento more. We have previously expressed the idea that evolution involves malignant neoplasms as testing grounds for new regulatory RNAs and proteins, which are subsequently distributed throughout the biosphere. The presence of a clear mind is an evolutionary asset of an old cancer patient. She passes on her experience to her descendants using a second signaling system, thus counteracting the inexorable passage of time.
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