Chronic gastritis and carcinogenesis issues
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Keywords

chronic gastritis, gastric mucosa, gastric cancer, intestinal metaplasia, atrophy, H. pylori, gastrin, pepsinogen, interleukin

How to Cite

Karimov, M. M., Sobirova, G. N., & Abdullayeva, U. K. (2019). Chronic gastritis and carcinogenesis issues. Herald of Pancreatic Club, 45(4), 65-70. https://doi.org/10.33149/vkp.2019.04.09

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Abstract

Risk factors contributing to the transformation of chronic atrophic gastritis into gastric cancer are analyzed. Detection and monitoring of patients with precancerous conditions/lesions (precancerous changes), proper screening of H. pylori make early diagnosis of gastric cancer real. Features of precancerous conditions are given in order of increasing risk of developing gastric cancer. Adenomatous polyps of the stomach take the first place. Subsequent precancerous conditions include: cancer of the operated stomach, Menetria disease (hypertrophic gastropathy), B12-deficient anemia, and gastric ulcer. A definition of intestinal metaplasia subtypes is proposed as a risk factor for gastric cancer, dividing into complete and incomplete one, taking into account reduction in the expression of gastric mucins MUC1, MUC5AC and MUC6. Currently, the development of gastric cancer (mainly of the “intestinal type”) is considered as a multistage process involving the sequence of mucosal change, such as chronic inflammation, atrophy, intestinal metaplasia, dysplasia and adenocarcinoma. Role of the organism’s genetic susceptibility to H. pylori infection, factors of pathogenicity contributing to epithelial metaplasia, are analyzed. Role of Toll-like type 4 receptors (TLR4) involved in the recognition of H. pylori is clarified. It is with this type of receptors that the development of an excessive immune response of the host is associated, resulting in damage to the mucous membrane in H. pylori-infected individuals. In particular, carriers of TLR4+896A> G polymorphism have a more severe atrophy of the stomach and degree of inflammation, as well as an increased risk of non-cardiac gastric cancer.

https://doi.org/10.33149/vkp.2019.04.09
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References

Амиева М. Р., Эль-Омар Е. М. Хозяевно-бактериальные взаимодействия при хеликобактере. Гастроэнтерология. 2008. Вып. 134, № 1. С. 306–332.
Прохоров А. В. Рак желудка у пациентов моложе 30 лет. Евразийский онколог. журнал. 2014. № 2. С. 64–68.
Чиссов В. И. Злокачественные новообразования в России в 2011 году. Москва, 2012. 260 с.
Bernini M. Family history of gastric cancer: a correlation between epidemiologic findings and clinical data. Gastric Cancer. 2006. Vol. 9, No 1. P. 9–13.
Buffart Т. Е. Gastric cancers in young and elderly patients show different genomic profiles. J. Pathol. 2007. Vol. 211. P. 45–51.
Correa P. The biological model of gastric carcinogenesis. ARC Sci. Publ. 2004. Vol. 157. P. 301–310.
Dinis-Ribeiro M. Meta-analysis on the validity of pepsinogen test for gastric carcinoma, dysplasia or chronic atrophic gastritis screening. J. Med. Screen. 2004. Vol. 11. P. 141–147.
Ferlay J. Cancer incidence and mortality patterns in Europe — estimates. European Journal of Cancer. 2013. Vol. 49. P. 1374–1403.
Fuccio L. Meta-analysis: can Helicobacter pylori eradication treatment reduce the risk for gastric cancer? Annals of internal medicine. 2009. Vol. 151, No 2. P. 121–128.
Fuccio L. Systematic review: Helicobacter pylori eradication for the prevention of gastric cancer. Alimentary pharmacology & therapeutics. 2007. Vol. 25. No. 2. P. 133–141.
Guindi M., Riddell R. H. The pathology of epithelial pre-malignancy of the gastrointestinal tract. Best Pract. Res. Clin. Gastroenterol. 2001. Vol. 15. P. 191–210.
Gutierrez-Gonzalez L., Wright N. A. Biology of intestinal metaplasia in 2008: more than a simple phenotypic alteration. Dig. Liver Dis. 2008. Vol. 40. P. 510–522.
Maruta F., Sugiyama A., Ishizone S. Eradication of Helicobacter pylori decreases mucosal alterations linked to gastric carcinogenesis in Mongolian gerbils. J. Gastroenterol. 2005. Vol. 40. P. 104–105.
Mera R., Fontham E. T., Bravo L. E. Long term follow up of patients treated for Helicobacter pylori infection. Gut. 2005. Vol. 54. P. 1536–1540.
Nozaki K., Shimizu N., Ikehara Y. Effect of early eradication on Helicobacter pylorirelated gastric carcinogenesis in Mongolian gerbils. Cancer Sci. 2003. Vol. 94. P. 235–239.
Ohata H., Kitauchi S., Yoshimura N. Progression of chronic atrophic gastritis associated with Helicobacter pylori infection increases risk of gastric cancer. Int. J. Cancer. 2004. Vol. 109. P. 138–143.
Pharoah P. D., Lee P. G. International Gastric Cancer Linkage Consortium Incidcnce of gastric cancer and breast cancer in CDH1 (Ecadherin) mutation carriers from hereditary diffuse gastric cancer families. Gut. 2013. Vol. 62. No 5. Р. 676–682.
Pimanov S. I., Makarenko E. V., Voropaeva A. V. Helicobacter pylori eradication improves gastric histology and decreases serum gastrin, pepsinogen I and pepsinogen II levels in patients with duodenal ulcer. J. Gastroenterol. Hepatol. 2008. Vol. 23. P. 1666–671.
RokkasТ., Pistiolas D., Sechopoulos P. The long-term impact of Helicobacter pylori eradication on gastric histology: a systematic review and metaanalysis. Helicobacter. 2007. Vol. 12, No 2. P. 32–38.
Shah М. А., Kelsen D. P. Gastric cancer: a primer on the epidemiology and biology of the disease and an overview of the medical management of advanced disease. J. Natl. Compr. Cane. Netw. 2010. Vol. 8. P. 437–447.
Shimizu N., Ikehara Y., lnada K. Eradication diminishes enhancing effects of Helicobacter pylori infection on glandular stomach carcinogenesis in Mongolian gerbils. Cancer Res. 2000. Vol. 60. P. 1512–1514.
Take S., Mizuno M., Ishiki K. The effect of eradicating Helicobacter pylori on the development of gastric cancer in patients with peptic ulcer disease. Am. J. Gastroenterol. 2005. Vol. 100. P. 1037–1042.
Take S., Mizuno M., Ishiki K. The long-term risk of gastric cancer after the successful eradication of Helicobacter pylori. J. Gastroenterol. 2011. Vol. 46. P. 318–324.
Wang J., Xu L., Shi R. Gastric atrophy and intestinal metaplasia before and after Helicobacter pylori eradication: a meta-analysis. Digestion. 2011. Vol. 83. P. 253–260.
Yaghoobi M., Bijarchi R., Narod S. A. Family history and the risk of gastric cancer. Br. J. Cancer. 2009. Vol. 102. P. 237– 242
Yamaji Y., Watabe H., Yoshida H. High-risk population for gastric cancer development based on serum pepsinogen status and lifestyle factors. Helicobacter. 2009. Vol. 14. P. 81–86.