Peculiarities of values of acetylcholine concentration and cholinesterase activity in serum of patients with alcoholic chronic pancreatitis and duodenal ulcer
Vol 39 No 2 (2018), ORIGINAL RESEARCH
Vol 39 No 2 (2018)

Peculiarities of values of acetylcholine concentration and cholinesterase activity in serum of patients with alcoholic chronic pancreatitis and duodenal ulcer

ORIGINAL RESEARCH
https://doi.org/10.33149/vkp.2018.02.04
Published June 6, 2018
I. E. Trubitsyna
Moscow Clinical Scientific Center n. a. A. S. Loginov
A. S. Gulyaev
Moscow Clinical Scientific Center n. a. A. S. Loginov
L. V. Vinokurova
Moscow Clinical Scientific Center n. a. A. S. Loginov
T. V. Tarasova
Moscow Clinical Scientific Center n. a. A. S. Loginov
G. A. Drozdova
Moscow Clinical Scientific Center n. a. A. S. Loginov
PDF (Русский)
DOCX

Keywords

acetylcholine, cholinesterase, duodenal ulcer, alcoholic chronic pancreatitis, Kruskall — Wallis test, Nemenyi test

How to Cite

Trubitsyna, I. E., Gulyaev, A. S., Vinokurova, L. V., Tarasova, T. V., & Drozdova, G. A. (2018). Peculiarities of values of acetylcholine concentration and cholinesterase activity in serum of patients with alcoholic chronic pancreatitis and duodenal ulcer. Herald of Pancreatic Club, 39(2), 25-28. https://doi.org/10.33149/vkp.2018.02.04
ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver

Download Citation

Endnote/Zotero/Mendeley (RIS) BibTeX

Abstract views: 215
PDF Downloads: 240 PDF Downloads: 115

Abstract

Introduction. There are a lot of pathogenic factors involved in development of polyetiologic diseases. Acetylcholine (AC) is known as first-order mediator as it plays an important role in development and maintenance of pathological processes. In this article we provide data on AC concentration in blood serum of patients with duodenal ulcer, alcoholic chronic pancreatitis and control group as well as activity of cholinesterase.

The aim of this study was to identify a role played by AC in pathological process during disease, which may complicate a course of the disease as a bad prognostic factor.

Results and discussion. We divided AC concentration into three types in the control group: low — 0.46–1.0 mmol/l (60% of individuals), moderate — 1.02–1.5 mmol/l (30%) , and high — more than 1.5 mmol/l (10%).

Conclusion. We suppose that cholinesterase activity and AC concentration depend on localization of pathological process.

https://doi.org/10.33149/vkp.2018.02.04
PDF (Русский)
DOCX

References

1. Нарушение гуморальной регуляции внешнесекреторной функции поджелудочной железы при хроническом панкреатите / Л. В. Винокурова, Э. Р. Валитова, И. Е. Трубицына [и др.] // Терапевтический архив. – 2007. – Т. 79. – № 2. – С. 44–48.
2. Трубицына И. Е. Биологически активные вещества как факторы агрессии и защиты при язве желудка (экспериментально-клиническое исследование) : автореф. докторской диссертации / И. Е. Трубицына. – М., 2004. – С. 29.
3. Трубицына И. Е. Вариации и частота распределения количественного значения ацетилхолина и холинэстеразной активности в сыворотке крови у здоровых лиц / И. Е. Трубицына, В. Н. Дроздов, М. В. Рудь // Экспериментальная и клиническая гастроэнтерология. – 2007. – № 3. – С. 78–81.
4. Kruskal W. H. Use of ranks in one-criterion variance analysis / W. H. Kruskal, W. A. Wallis // Journal of the American Statistical Association. – 1952. – Vol. 47, No 260. – P. 583–621.
5. Nemenyi P. B. Distribution-free multiple comparisons : PhD thesis / P. B. Nemenyi. – Princeton University, 1963.
6. Pohlert T. The Pairwise Multiple Comparison of Mean Ranks Package (PMCMR). R-package. – 2014. – Available at : http://CRAN.R-project.org/package=PMCMR
7. R Core Team. R: a language and environment for statistical computing / R Foundation for Statistical Computing, Vienna, Austria. – 2015. – Available at https://www.R-project.org/

Most read articles by the same author(s)