Metabolic acidosis as an important factor of pathogenesis of chronic pancreatitis
PDF (Українська)
DOCX

Keywords

chronic pancreatitis, metabolic acidosis, pathogenesis, trophic insufficiency, treatment programme

How to Cite

Zemlyak, O. S., & Babinets, L. S. (2018). Metabolic acidosis as an important factor of pathogenesis of chronic pancreatitis. Herald of Pancreatic Club, 40(3), 17-19. https://doi.org/10.33149/vkp.2018.03.03

Abstract views: 71
PDF Downloads: 115 PDF Downloads: 35

Abstract

Article presents the results of the analysis of scientific literature on the role of metabolic acidosis in the pathogenesis of chronic pancreatitis. It is stated that metabolic acidosis is an important predictive factor in the formation and deepening of trophic insufficiency, which further reduces the quality of life of patients with chronic pancreatitis and worsens the prognosis. This motivates the need to take into account the presence of metabolic acidosis during the development of a complex treatment program for such patients.

https://doi.org/10.33149/vkp.2018.03.03
PDF (Українська)
DOCX

References

1. Калинин А. В. Хронический панкреатит: распространенность, этиология, патогенез, классификация и клиническая характеристика этиологических форм / А. В. Калинин // Клин. перспект. гастроэнтерол., гепатол. – 2006. – № 6. – С. 5–15.
2. Маев И. В. Панкреатология сегодня / И. В. Маев, А. Н. Казюлин, Ю. А. Кучерявый // Трудные вопросы гастроэнтерологии. – Донецк, 2007. – С. 12–17.
3. Некачалов В. В. Патология костей и суставов. Руководство / В. В. Некачалов. – СПб. : Сотис, 2000. – 288 с.
4. Остеодефіцит і вплив супутньої патології на його глибину при хронічному панкреатиті / Л. С. Бабінець, О. С. Квасніцька, Л. М. Мігенько, О. Я. Пінкевич. – Буковинський медичний вісник. – Т. 15, № 2 (58). – 2011.
5. Руководство по анестезиологии / Под ред. А. Р. Эйткенхеда, Г. Смита. – В 2 томах. – Том 1. – М. : Медицина, 1999.
6. Acute and chronic pancreatitis – diseases on the rise : a study of hospital admissions in England 1989/90–1999/2000 / A. Tinto, D. A. Lloyd, J. Y. Kang [et al.] // Aliment. Pharmacol. Ther. – 2002.
7. Case R. M. The origin and secretion of pancreatic juice bicarbonate / R. M. Case, T. Scratcerd, D. A. Wynner // J. Physiol. – 1970. – P. 1–15.
8. Guyton A. C. Human physiology and mechanism of disease / A. C. Guyton. – 1987. – 499 p.
9. Initial pathophysiological changes in chronic pancreatitis induced by pancreatic ductular obstruction / S. Matsuno, Y. Sasaki, M. Kobari [et al.] // Tohoku Journal of Experimental Medicine. – 1991. – Vol. 163, No 3. – P. 199–210.
10. Introduction to Enzymes. Worthington Enzyme Manual. Worthington Biochemical Corporation. 2010. http://www.worthington-biochem.com/ introbiochem/default.html
11. Johnson L. R. Essential medical physiology / L. R. Johnson, J. H. Byrne. – USA : Academic Press, 2003.
12. Lieb J. G. II. Pancreatic function testing: here to stay for the 21st century / J. G. Lieb II, P. V. Draganov // World J. Gastroenterol. – 2008. – Vol. 20. – P. 3149–3158.
13. Mc Clave S. A. Feeding the chronically ill patient / S. A. Mc Clave // Audio-Digest Gastroenterology. 42nd Annual Gastroenterology Update. The Cleveland Clinic, Department of Gastroenterology and Hepatology. – 2006.
14. Melamed P. Chronic metabolic acidosis destroys pancreas. Biotherapy Clinic of San Francisco, USA / P. Melamed, F. Melamed // JOP. – 2014. – Vol. 15, No 6. – P. 552–560.
15. Sarles H. Chronic pancreatitis: etiology and pathophysiology / H. Sarles. – New York : Raven Press, 1986.
16. Saunders J. H. Pancreatic extracts in the treatment of pancreatic exocrine insufficiency / J. H. Saunders, K. G. Wormsley // Gut. – 1975. – Vol. 16. – P. 157–162.
17. Scratcherd T. The secretion of electrolytes by the pancreas / T. Scratcherd, R. M. Case // Am. J. Clin. Nutrition. – 1973. – P. 326–339.
18. The source of pancreatic juice bicarbonate / E. O. Ball, H. F. Tucker, A. K. Solomon, B. Vennesland // J. Biol. Chem. – 1941. – Vol. 119.
19. Ströhle A. Estimation of the diet-dependent net acid load in 229 worldwide historically studied hunter-gatherer societies / A. Ströhle, A. Hahn, A. Sebastian // Am. J. Clin. Nutr. – 2010. – Vol. 91. – P. 406–412.
20. Talamini G. Duodenal acidity may increase the risk of pancreatic cancer in the course of chronic pancreatitis: an etiopathogenetic hypothesis / G. Talamini // JOP. – 2005. – Vol. 6. – P. 122–127.