Keywords
stomach, Helicobacter pylori, strains, genotype, non-steroidal anti-inflammatory drugs
How to Cite
Shirinskaya, N. V., Pomorgaylo, Y. G., Vas’kina, T. V., & Kirichenko, N. P. (2017). Genotype of Helicobacter pylori and non-steroidal anti-inflammatory drugs. Herald of Pancreatic Club, 37(4), 68-72. https://doi.org/10.33149/vkp.2017.04.11
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Abstract
Studying strains of Helicobacter pylori in a mucous membrane of a stomach in adult patients taking non-steroidal anti-inflammatory drugs was carried out. Helicobacter pylori genotyping was performed by technique of polymerase chain reaction. Results of the conducted research, despite some heterogeneity, show existence of statistically significant differences depending on existence of erosive and ulcer changes and a factor of non-steroidal anti-inflammatory drugs intake.
References
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2. Ширинская Н. В. НПВП-гастропатия и Helicobacter pylori: больше вопросов, чем ответов / Н. В. Ширинская, В. А. Ахмедов // Экспериментальная и клиническая гастроэнтерология. – 2010. – № 9. –С. 116–120.
3. Aspirin inhibits the growth of Helicobacter pylori and enhances its susceptibility to antimicrobial agents / W. H. Wang, W. M. Wong, D. Dailidiene [et al.] // Gut. – 2003. – Vol. 52. – P. 490–495.
4. Barkin J. The relation between Helicobacter pylori and nonsteroidal anti-inflammatory drugs /J. Barkin // Am. J. Med. – 1998. – Vol. 105, No 5A. – P. 22–27.
5. Brooks P. M. Non-steroidal anti-inflammatory drugs: differences and similarities / P. M. Brooks, R. O. Day // N. Engl. J. Med. – 1993. – Vol. 324. – P. 1716–1725.
6. Chan F. K. L. NSAID-induced peptic ulcers and Helicobacter pylori infection / F. K. L. Chan // Drug Safety. – 2005. – No 28. – P. 287–300.
7. Cover T. L. Purification and characterization of the vacuolating toxin from Helicobacter pylori / T. L. Cover, M. J. Blaser // J. Biol. Chem. – 1992. – Vol. 267. – P. 10570–10575.
8. Cover T. L. The vacuolating cytotoxin of Helicobacter pylori / T. L. Cover // Mol. Microbiol. – 1996. – Vol. 20. – P. 241–246.
9. Effect of aspirin and celecoxib on Helicobacter pylori in vitro / H. X. Ma, W. H. Wang, W. H. Hu [et al.] // Shijie Huaren Xiaohua Zazhi. – 2006. – Vol. 14. – P. 2747–2752.
10. Effect of cyclo-oxygenase inhibitors on Helicobacter pylori susceptibility to metronidazole and clarithromycin / Q. Gu, H. H. Xia, W. H. Wang [et al.] // Aliment. Pharmacol. Ther. – 2004. – Vol. 20. – P. 675–681.
11. Effect of Helicobacter pylori colonisation on gastric mucosal eicosanoid synthesis in patients taking non-steroidal anti-inflammatory drugs / N. Hudson, M. Balsitis, F. Filipowicz [et al.] // Gut. – 1993. – Vol. 34. – P. 748–751.
12. Huang J. Q. Role of Helicobacter pylori infection and non-steroidal anti-inflammatory drugs in peptic-ulcer disease : a meta-analysis / J. Q. Huang, S. Sridhar, R. H. Hunt // Lancet. – 2002. – Vol. 359. – P. 14–22.
13. Immunobiology of Helicobacter pylori infection / J. L. Telford, A. Covacci, R. Rappuoli [et al.] // Curr. Opin. Immunol. – 1997. – Vol. 9. – P. 498–503.
14. Inhibitory effects of aspirin and indometacin on the growth of Helicobacter pylori in vitro / W. H. Wang, F. L. Hu, B. C. Y. Wong [et al.] // Chin. J. Dig. Dis. – 2002. – Vol. 3. – P. 172–177.
15. Non-steroidal anti-inflammatory drugs have bacteriostatic and bactericidal activity against Helicobacter pylori / H. Shirin, S. F. Moss, S. Kancherla [et al.] // J. Gastroenterol. Hepatol. – 2006. – Vol.21. – P. 1388–1393.
16. Proença-Modena J. L. Helicobacter pylori: phenotypes, genotypes and virulence genes / J. L. Proença-Modena, G. O. Acrani, M. Brocchi // Future Microbiol. – 2009. – Vol. 4, No 2. – P. 223–240.
17. Randomised controlled trial of Helicobacter pylori eradication in patients on non-steroidal anti-inflammatory drugs : HELP NSAIDs study. Helicobacter Eradication for Lesion Prevention / C. J. Hawkey, Z. Tulassay, L. Szczepanski [et al.] // Lancet. – 1998. – Vol. 352. – P. 1016–1021.
18. Suzuki R. Molecular epidemiology, population genetics, and pathogenic role of Helicobacter pylori / R. Suzuki, S. Shiota, Y.Yamaoka // Infect. Genet. Evol. – 2012. – Vol. 12, No 2. – P. 203–213.
19. Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion / S. Odenbreit, J. Puls, B. Sedlmaier [et al.] // Science. – 2000. – Vol. 287. – P. 1497–1500.
20. Walker M. M. Helicobacter pylori infection and the pathogenesis of duodenal ulceration / M. M. Walker, J. E. Crabtree // Ann. N. Y. Acad. Sci. – 1998. –Vol. 859. – P. 96–111.