Histostructure of pancreas in patients with autoimmune pancreatitis type I and II: connection with the level of IgG4-positive plasma cells
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pancreatitis, lgG4, histological techniques, histostructure of pancreas, plasma cells

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Gaidar, Y. A., Oshmyanska, N. Y., & Halenko, A. P. (2017). Histostructure of pancreas in patients with autoimmune pancreatitis type I and II: connection with the level of IgG4-positive plasma cells. Herald of Pancreatic Club, 34(1), 28-31. https://doi.org/10.33149/vkp.2017.01.05

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Differential diagnosis of autoimmune pancreatitis apart from everything else is based on specifics of immunoglobulin G4 involvement into the pathogenesis.

Aim is to analyze two forms of autoimmune pancreatitis and their relation to the level of IgG4-positive plasma cells.

Methods and results. The present study was conducted on 54 patients with chronic pancreatitis, from which 15 cases with autoimmune pancreatitis were selected by using morphological and immunohistochemical methods.

Conclusion. It has been established that for autoimmune pancreatitis type I dense lymphocytic periductal infiltrate, multilevel fibrosis, obliterating venulitis and high IgG4-positive plasma cells in the pancreas (>30 per high power field) were typical. In the cases of autoimmune pancreatitis type II, besides the specific histopathological signs of AIP, significantly epithelial damage of pancreatic ducts by leukocytes, low levels of IgG4-PPC in the pancreas and focal lesions on stages I–III of disease (80%) were observed.

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1. Autoimmune pancreatitis with histologically proven lymphoplasmacytic sclerosing pancreatitis with granulocytic epithelial lesions / T. Ikeura, M. Takaoka, K. Uchida [et al.] // International Medicine. – 2012. – Vol. 51, No 7. – P. 733–737.
2. Chronic pancreatitis caused by an autoimmune abnormality. Proposal of the concept of autoimmune pancreatitis / K. Yoshida, F. Toki, T. Takeuchi [et al.] // Dig. Dis. Sci. – 1995. – Vol. 40, No 7. – P. 1561–1568.
3. Deshpande V. The pathology of IgG4-related disease: critical issues and challenges / V. Deshpande // J. Semin. Diagn. Pathol. – 2012. – Vol. 29, No 4. – P. 191–196.
4. Histopathological features of diagnostic and clinical relevance in autoimmune pancreatitis: a study on 53 resection specimens and 9 biopsy specimens / G. Zamboni, J. Liittges, P. Capelli [et al.] // Wirchows Arch. – 2004. – Vol. 445, No 6. – P. 552–563.
5. Idiopathic chronic pancreatitis with periductal lymphoplasmacytic infiltration. Clinicopathologic features of 35 cases / K. Notohara, L. J. Burgart, D. Yadav [et al.] // American Journal of Surg. Pathol. – 2003. – Vol. 27. – P. 1119–1127.
6. IgG4-related disease: historical overview and pathology of hematological disorders / Y. Sato, K. Notohara, M. Kojima [et al.] // Pathology International. – 2010. – Vol. 60. – P. 247–258.
7. International consensus diagnostic criteria for autoimmune pancreatitis: guidelines of the International Association of Pancreatology / T. Shimosegawa, S. T. Chari, L. Frulloni [et al.] // Pancreas. – 2011. – Vol. 40. – P. 352–358.