Abstract
Objective. To identify ways to implement the autoimmune process in patients with combined course of chronic obstructive pulmonary disease (COPD) and chronic pancreatitis (CP).
Materials and methods. The study has been held for the peculiarities of the development of metabolic intoxication and formation of auto immune reactions in 79 patients with COPD and with combined course of COPD and CP.
Results and discussion. The presence of concomitant CP exacerbates the syndrome of endogenous intoxication and the imbalance oi regulatory mechanisms of both cellular and humoral immunity, which significantly increases the risk of autoimmune complications.
Conclusions. This fact allows us to consider the presence of concomitant CP in patients with COPD as unfavorable prognostic factor.
References
2. Черный В. И. Нарушения иммунитета при критических состояниях. Особенности диагностики / В. И. Черный, А. Н. Нестеренко // Внутр. мед. – 2007. – № 3. – С. 25–38.
3. Шано В. П. Синдром эндогенной интоксикации / В. П. Шано, Е. А. Кучер // Острые и неотложные состояния в практике врача. – 2011. – № 1. –С. 35–41.
4. Danilova N. The evolution of adaptive immunity / N. Danilova // Adv. Exp. Med. Biol. – 2012. – Vol. 738. – P. 218–235.
5. Humoral innate immune response and disease / S. N. Shishido, S. Varahan, K. Yuan [et al.] // Clin. Immunol. – 2012. – Vol. 144, No 2. – P. 142–158.