Physicochemical properties of blood and urine in patients with alcohol-induced chronic pancreatitis against the background of obesity
Vol 60 No 3 (2023), Articles
Vol 60 No 3 (2023)

Physicochemical properties of blood and urine in patients with alcohol-induced chronic pancreatitis against the background of obesity

Articles
https://doi.org/10.33149/vkp.2023.03.07
Published July 11, 2023
N. B. Gubergrits
“Into-Sana” Multifield Clinic
N. V. Byelyayeva
“Into-Sana” Multifield Clinic
S. S. Severin
Donetsk National Medical University
E. O. Severina
Donetsk National Medical University
PDF (Українська)

Keywords

chronic alcohol-induced pancreatitis, obesity, tensiometry, rheometry, dynamic surface tension, viscoelasticity, relaxation time

How to Cite

Gubergrits, N. B., Byelyayeva, N. V., Severin, S. S., & Severina, E. O. (2023). Physicochemical properties of blood and urine in patients with alcohol-induced chronic pancreatitis against the background of obesity. Herald of Pancreatic Club, 60(3), 51-55. https://doi.org/10.33149/vkp.2023.03.07
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Abstract

In this article, the authors present the results of their studies of the physicochemical properties of blood and urine in patients with chronic alcohol-induced pancreatitis (CAP) combined with obesity.

110 patients with CAP in the acute stage against the background of obesity were examined. The ages of the examined patients ranged from 23 to 60. There were 77 (70.0%) men and 33 (30.0%) women among the patients. We also examined 30 almost healthy people aged 20 to 60 (the control group).

There are significant changes in the physicochemical properties of blood and urine in patients with CAP against the background of obesity. Indices of interfacial tensiometry and rheometry of these biological fluids correlate with other clinical, laboratory, and instrumental data in patients with CAP combined with obesity. This allows us to recommend the assessment of dynamic surface tension and rheometric indices of blood and urine for screening and an integral assessment of the functional state of the pancreas in comorbidity. In addition, it is reasonable to use the results of interfacial tensiometry and rheometry for screening the metabolic syndrome in patients with CAP against the background of obesity. In the metabolic syndrome, there is a significant increase in the surface tension 3 of the blood; in the absence of this syndrome, on the contrary, the surface tension 3 of the blood is significantly reduced.

In patients with biliary sludge and cholelithiasis, the blood viscoelasticity index (E) was significantly lower (23.18±1.07 mN/m), while without concomitant diseases of the biliary tract, the blood E was equal to 27.84±1.08 mN/m (p<0.05). Both with and without changes in the biliary system, blood E in patients with CAP against the background of obesity was significantly lower than in the control group.

The prospects of research are to study the dynamics of tensiometry and rheometry of biological fluids in CAP combined with obesity under the influence of treatment in order to study the possibility of using these indices in the integrated assessment of the effectiveness of therapy.

https://doi.org/10.33149/vkp.2023.03.07
PDF (Українська)

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