Stem mesenchymal bone marrow cells in the treatment of ulcerative colitis based on morphological and immunological research (literature review)
Vol 38 No 1 (2018), NOT ONLY PANCREATOLOGY
Vol 38 No 1 (2018)

Stem mesenchymal bone marrow cells in the treatment of ulcerative colitis based on morphological and immunological research (literature review)

NOT ONLY PANCREATOLOGY
https://doi.org/10.33149/vkp.2018.01.09
Published March 6, 2018
V. S. Rakhmetova
National Scientific Medical Research Center
A. B. Orazbayeva
National Scientific Medical Research Center
A. Y. Amrenova
National Scientific Medical Research Center
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Keywords

ulcerative colitis, mesenchymal stem cells, transplantation, regenerative medicine, clinical studies

How to Cite

Rakhmetova, V. S., Orazbayeva, A. B., & Amrenova, A. Y. (2018). Stem mesenchymal bone marrow cells in the treatment of ulcerative colitis based on morphological and immunological research (literature review). Herald of Pancreatic Club, 38(1), 59-63. https://doi.org/10.33149/vkp.2018.01.09
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Abstract

The use of stem cells in complex therapy of inflammatory bowel diseases has became perspective therapeutic strategy. Mesenchymal stem cells, which have immunomodulatory, anti-inflammatory properties and high regenerative potential, are used for therapy of inflammatory bowel disease, what is making them attractive to clinical application. According to the results of the conducted studies, mesenchymal stem cells improve clinical and microscopic manifestations of colitis, reduce system and local production of pro-inflammatory cytokines, suppress inflammatory process, stimulating tissue regeneration at the same time, promote the increase in the duration of remission of a disease, reduce the risk of the relapse of ulcerative colitis. Preliminary results of clinical and experimental studies carried out in the world justify the relevance, prospects and sufficient safety of the transplantation method of allogenic mesenchymal stromal cells of bone marrow for treatment of patients with the ulcerative colitis.

https://doi.org/10.33149/vkp.2018.01.09
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DOCX

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